Sympathetic Nerves Of Cervical Posterior Longitudinal Ligament In The Pathogenesy Of Cervical Spondylosis With Cervidal Vetigo

Objective:The cervical spondylosis with cervical vertigo is a frequent and complicated disease which is very difficult to effectively diagnose and treat in clinic.At present,there are many contradictions between the theory and clinical picture,and the main reason of which was the ambiguity of exact pathogenesis.In the prior reseach,we had found that there are large numbers of sympathetic postganglionic fibers on the cervical PLL,and they have some feature in morphology and distribution.Therefore,we consider that some other reasons maybe lead to the cervical vertigo and sympathetic symptom except the vertebrarterial factor,and the sympathetic nerve fibers on the posterior longitudinal ligament are the physiological basis of perceiving pathological stimulation from cervical vertebral degeneration,their abnormal excitement from stimulation may be an important cause triggering cervical vertigo.This study is base on the prior research,and is to continue research the source of sympathetic nerve fibers on the PLL and its functional relationship with the cervical artery.The experimental result can provide helpful experimental clues for better know this disease and further mechanism study.Method:â‘ The superior cervical sympathetic ganglia,middle cervical sympathetic ganglia and inferior cervical sympathetic ganglia of New Zealand rabbits were injected into HRP and BDA respectively by anterograde tract-tracing.In blank group,the 0.9%isotonic Na was substituted for the tracer to chloride negative control.The rabbits were perfused and fixated routinely after some time,and then,the cervical PLL were excised and sliced with a cryostat for color reaction.Each group PLL sections were observed and photographed by light microscope to make clear the projection and distribution of sympathic postganglionic fibres on cervical PLL.â‘¡To make clear the relationship between sympathetic nerve on posterior longitudinal ligament and cervical artery and heart function by stimulate the PLL with electrode and record the blood flow of internal carotid artery and vertebral artery,heart function and arterial pressure simultaneously.Result:â‘ These positive results were seen on all sections of cervical PLL in three groups,and those on the intervertebral sector were more than the vertebral sector.No positive results were observed in the control sections.The distribution of the PLL in three cervical sympathetic ganglia was conduplicate.â‘¡The cervical PLL will cause that the blood flow of cervical artery(internal carotid artery and vertebral artery) quickly and transiently descend,and that the LVP, dp/dtmax and SAP quickly heighten when it is stimulated.Those targets haven't changed obviously when the cervical PLL which had injected into lidocaine be stimulated.Conclusion:â‘ There are direct projection between the cervical sympathetic ganglia and cervical PLL.The sympathetic postganglionic fibre on the cervical PLL was directly come from the cervical sympathetic ganglia.â‘¡The cervical PLL will cause vasoconstriction of the cervical artery(internal carotid artery and vertebral artery) and positive inotropic effect of heart when it is stimulated,and which lead to the blood flow of them quickly descend and heighten. The blood flow quickly and transiently descend was the foundation of ischemia of internal ear,and the decompensation of the cervical and encranial compensatory artery may be the key factor that result in cervical vertigo and other complicated symptoms.