Acupuncture Functional Mri Leukoaraiosis Mild Cognitive Impairment

Vascular cognitive impairment refers to the risk factors derived from blood vessels caused by a variety of levels and types of cognitive impairment,containing the vascular mild cognitive impairment,vascular dementia and mixed dementia. Early detection,early diagnosis,early intervention to the mild vascular cognitive impairment can prevent or delay the occurrence and progress of dementia,which is of significance and an extremely important social,economic and medical value.There is heterogeneity of the factors which lead to vascular mild cognitive impairment,including leukoaraiosis,cerebral artery stenosis,cerebral infarction, cerebral hemorrhage,hypertension,diabetes and so on.To found leukoaraiosis with the application of magnetic resonance technology in the elderly people,the result in the general prevalence rate reached 49.7 percent,and its prevalence increased with age increased,almost 100 percent for the people over 80 years. Leukoaraiosis is not only a pathological image changes,but quite important for its clinical performance in term of cognitive impairment,therefore both imaging and pathology of leukoaraiosis changing has become a good entry point for studying the vascular mild Cognitive.Acupuncture is an effective way for the treatment of dementia,most clinical assessments for the improvement of the patients based on a variety of neuropsychological scales,there is no neuroimaging studies yet to be used as the objective standards for dementia.Functional magnetic resonance technology is an important type of medical data visualization technology,which can function in the human brain and objective information visualized display.Therefore,the functional magnetic resonance technology is an advanced method to study acupuncture intervention for mild cognitive impairment and efficacy of the mechanism of objective standards.In the study of leukoaraiosis in mild cognitive impairment (LAMCI),functional magnetic resonance is applied with the reference of clinical practice,long-term acupuncture intervention,through the neuropsychological scale evaluation of mild leukoaraiosis clinical changes has been done,on the basis of this study,the neurotransmitter changes of the patients of leukoaraiosis mild cognitive impairment can be observed before and after acupuncture intervention with functional magnetic resonance brain,and the mechanism of acupuncture intervention can be unveiled.Two parts including Literature Summary and Clinical Trials.Literature SummaryTo summarize ancient Chinese medicine literature on the vascular dementia, Focus on the treatment and theoretical study.The application of functional magnetic resonance on mild cognitive impairment and the treatment of acupuncture were analyzed in this part,also pointed out the current existing problems,and the directions of the development in the future.Clinical TrialsAcupuncture for mild cognitive impairment leukoaraiosis impact of functional magnetic resonance.To observe the neurotransmitter changes before and after acupuncture intervention in mild cognitive impairment with the functional magnetic resonance brain in the purpose of and the situation.LAMCI 23 cases,and normal subjects(control group) 13 cases were observed. LAMCI was further divided into test acupuncture group and the natural process of group,acupuncture treatment for three months,Dynamic observed the natural process of group for 3 months,neuropsychological evaluation and magnetic resonance spectroscopy check were executed in the beginning day and the end day. Neuropsychological assessment contains:MMSE and MoCA,MRI spectroscopy NAA/Cr,Cho/Cr,MI/Cr.Results:1.there was no significant difference between the LAMCI group and normal group for the NAA / Cr,Cho / Cr,MI / Cr test results in the post cingulate gyrus;2.Taking the age as the correction factors,eight cases of LAMCI group were re-tested with neurotransmitter compared with normal subjects group,NAA / Cr, Cho / Cr was no significant differences,LAMCI trial group was MI / Cr significantly increased,compared to the the other two groups,there were significantly differences;3.5 cases of LAMCI trial of acupuncture intervention were treated with acupuncture for 3 months,neuropsychological scores before the acupuncture were abnormal,but the neuropsychological scores became normal after acupuncture,in term of NAA / Cr,Cho / Cr,MI / Cr,there was no significant difference between Acupuncture group and the control group;4.The brain areas including the temporal lobe of the temporal gyrus(BA22), temporal in the back(BA21),temporal polar region(BA38);prefrontal cortex,the somatosensory(BA1) and pre-motor cortex(BA6) were activated before Acupuncture intervention,when the music hearing task started.Activated brain regions after acupuncture including the temporal gyrus(BA22);the orbital frontal leaf(BA11),the polar regions(BA10),cover of frontal lobe.There was significantly less areas activated than the promoter region of the former acupuncture group.Conclusions:1.Leukoaraiosis mild cognitive impairment related to the frontal and temporal lobes,the activated auditory cortex in the temporal lobe to start increasing,the prefrontal cortex is not activated when the hearing stimulation were started.Functional magnetic resonance can be a tool for the diagnosis of mild cognitive impairment,as well as the efficacy of acupuncture mechanism research based on visualization2.The neurotransmitter changes in the cingulated gyrus,with the MI / Cr ratio increased,which may be an objective indicator for the diagnosis of this disease when Leukoaraiosis mild cognitive impairment occurred3.Acupuncture can be used as an effective means of intervention for the mild cognitive impairment leukoaraiosis,which can reduce activated brain regions in order to raise the efficiency of the task when stimulation was processed,but a longer period of intervention was needed to explore whether there is any neurotransmitters changes in brain.