Depression is a common and frequently encountered disease with high incidence rate and high recurrence rate which seriously jeopardizes our health. The current diagnostic criteria are not perfect for its subtypes yet. Drug treatment is the main method to treat depression. However, the commonly used drugs have many side effects and are very expensive. It is hard for the patients to comply with the prescription. So when dealing with depression, Chinese medicine has an advantage over western medicine. But unanimous opinion has not been reached yet on its etiology, mechanism, syndrome patterns and treatment. Many doctors put forward their opinion from their own clinical experience. There is a discrepancy between syndrome patterns derived from clinical investigation and clinical practice due to the limitation of these methods. In determining treatment by pattern identified system of Chinese medicine, syndrome pattern is the key point. So, study of the syndrome characteristics of depression is of great importance before further research is conducted.On the basis of an overall sort of the pertinent literatures of depression, the study investigated primary depression patients who were diagnosed for the first time in order to exclude the intervention of somatic diseases, other mental disorders and drugs. The study was conducted in 7 units in Beijing and 611 patients meeting the criteria were enrolled. The study adopts the method of Bayesian network and other statistical methods to: 1. study the syndrome characteristics of depression; 2.analyze the distribution characteristics of the degree of depression and syndrome patterns in different people; 3. analyze the relationship between the syndrome of depression(syndrome elements and patterns), the seven factors of HAMD Depression Measuring Scale and the degree of depression so as to reveal the internal relationship between differentiation of symptoms and signs of Chinese medicine and the diagnosis of western medicine; 4. analyze the relationship between personal information (age, gender, birth season, etc), syndrome patterns and the factors of HAMD Depression Measuring Scale.The main results and conclusion:1. The pathomechanism elements, sites of the disease and syndrome patterns were picked up. Nine pathomechanism elements are jing deficiency, qi deficiency, blood deficiency, yin deficiency, yang deficiency, stagnation of qi, blood stasis, phlegm dampness and fire heat. Four sites of the disease are the heart, kidney, liver and spleen. Eight syndrome patterns are syndrome of kidney deficiency and stagnation of liver-qi, syndrome of stagnation of liver-qi and spleen deficiency, syndrome of kidney and spleen deficiency, syndrome of breakdown of heart-kidney interaction, syndrome of deficiency of qi and blood, syndrome of phlegm and blood stasis biding together, syndrome of qi deficiency and blood stasis and syndrome of exuberant fire in the heart and liver. 2.The relationship between depression and personal information are as follows: (1)The distribution of depression varies in different people. People who are 30 to 50 most probably suffer from depression with the mean age 40.21±13.16 years old. Female is more likely to have depression and the ratio between male and female is 1:1.9. The incidence rate is higher in officials, office clerks, those who have received secondary and higher education, and who lack social communication and hobbies, live in the city and born in winter. (2) The degree of depression is related to the economic status, hobbies, family relation, self-care ability,housing condition, etc. (3) Some factors of HAMD Depression Measuring Scale are related to personal information. For instance, housing condition negatively correlates with anxiety/somatization factor, hobbies positively correlates with the degree of depression and years of age positively correlates with dyssomnia.3. The relation between syndrome patterns of Chinese medicine and personal information. (1)The distribution of syndrome patterns of depression differs according to people's age and self-care ability. (2) Some syndrome elements of depression are related to personal information. In people who have wide hobbies, the degree of jing deficiency and yang deficiency are lower than those who have not. (3) Some syndrome patterns of depression also correlate with personal information. The degree of kidney deficiency and stagnation of liver-qi and that of stagnation of liver-qi and spleen deficiency are lower in people who have wide hobbies than those who have not. Years of age positively correlates with the degree of deficiency of qi and blood, phlegm and blood stasis biding together and breakdown of heart-kidney interaction.4. The relation between syndrome patterns of depression and factors of HAMD Depression Measuring Scale: (1) Some elements of syndrome correlate with the factors of HAMD Depression Measuring Scale. Liver and heart are related to anxiety/somatization factor. Spleen correlates with body weight. Yang deficiency, qi deficiency, fire heat, stagnation of qi, and the liver contribute to cognitive handicap. Jing deficiency, yang deficiency, qi deficiency, blood deficiency, and the liver and spleen contribute to retardation factor. And yin deficiency, blood deficiency, phlegm dampness and blood stasis contribute to dyssomnia. (2) Some syndrome patterns of depression correlate with the factors of HAMD Depression Measuring Scale. Syndrome of stagnation of liver-qi and spleen deficiency and syndrome of exuberant fire in the heart and liver correlate with anxiety/somatization factor. Syndrome of kidney and spleen deficiency and syndrome of phlegm and blood stasis biding together correlate with body weight. Syndrome of kidney deficiency and stagnation of liver-qi, syndrome of stagnation of liver-qi and spleen deficiency, and syndrome of exuberant fire in the heart and liver contribute to cognitive handicap. All of the patterns correlate with retardation factor. Syndrome of breakdown of heart-kidney interaction, syndrome of qi deficiency and blood stasis, syndrome of deficiency of qi and blood, and syndrome of phlegm and blood stasis biding together correlate with dyssomnia. 5. The relation between syndrome patterns of depression and the degree of depression: (1) Some elements of syndrome, especially jing deficiency, correlate with the degree of depression. (2) Syndrome of kidney deficiency and stagnation of liver-qi is the most common syndrome pattern of depression which accounts for 29.1% of the cases.6. It indicates that kidney-jing deficiency is the main pathomechanism of depression, in which other pathomechanisms and internal organs are also involved. |