Experimental Study Of The Dihydropyridine Structure-activity Relationship

The chemical compounds, 1,4-dihydropyridines. (1,4 -DHPs), have been proved to be one of the most important chemical classes introduced into medical and biological sciences over the past twenty years and studies on their chemical and pharmacological properties are of great theoretical as well as practical significance. In the present study, 32 derivatives of DHPs were synthesized and their photostability, structure-activity relationship and pharmacological characteristics were investigated so that the structure-activity relationship between the substituents, C-3 and C-5, and the effect of the substituents, C-4, on photosensitivity could be further elucidated.SYNTHESIS OF 1, 4-DIHYDROPYRIDINESI. Synthesis of 2, 6-dimethyl-4-furyl or aryl-1, 4-dihydro-3, 5-pyridinedicarboxylate In the first experiment in our series, ten acetoacetates were synthesized from alcohol and diketen e as catalysized by triethylamine and they were mixed with ammonia to prepare 3-aminocrotonate.Moreover, some of the synthesized acetoacetates were employed for the production of 2-acetyl-3-( 2- furyl, 3- nitrophenyl, or 2-chlorophenyl)propenate by reacting with furfuraldehyde, 3-nitrobenzaldehyde and 2-chlorbenzaldehyde, Finally, 32...