Pancreatic Cancer Mortality Rate In The Chinese Population Folate Metabolism Genes The Mthfr, Ms, The Ts Polymorphisms And Pancreatic Cancer Association Studies

Pancreatic cancer is one of the most malignant tumors worldwide. The death to incidence ratio of pancreatic cancer is approximately 0.99:1. With more than 27,000 people dying from pancreatic cancer, it is the fourth leading cause of cancer death in the United States. It has been shown that mortality rate of pancreatic cancer in China has increased constantly over the last decades. But there is little descriptive documentation countrywide on its epidemiology. On the basis of data of demography and death collected through China's Disease Surveillance Point System (DSPS) over the period of 1991-2000, the distribution of mortality rate of pancreatic cancer was described in terms of age groups, gender, calendar year, rural/urban residence and administrative district.Results showed that a total of 1619 death cases attributed to pancreatic cancer (975 men and 644 women) were reported by the DSPS during 1991-2000. The reported, adjusted and age-standardized mortality rates increased from 1.46, 1.75, and 2.18 per 100,000 population in 1991 to 2.38, 3.06, and 3.26 per 100,000 populations in 2000. The majority (69.62%) of the deaths of pancreatic cancer were seen in the age group of 60 years and older. The mortality rate was higher for males than for females, but the male to female death rate ratios decreased during the 10 years. Our data also showed that the death rate of pancreatic cancer in urban areas was about 2-4 fold higher than that in rural areas, and in Northeast and East China, the death rates were higher than those in other 5 administrative districts. From the study, we can conclude that the death rate of pancreatic cancer was rising during the period 1991-2000 and the peak mortality of pancreatic cancer might arrive in China.