Shigella Flexneri 2a 301 Strain Genome Studies

Dysentery is the most serious infectious disease threatening the people's health in our country. The persons susceptible to dysentery include both adults and children and the mortality of infant patients is very high. According to the relevant statistics, bacillary dysentery accounts for 75% of the total cases of dysentery, which means bacillary dysentery is mainly caused by Bacillus dysenteriae. At present, no effective measures for preventing bacillary dysentery are available and the protective effect of inoculation is not so ideal (the protection rate is about 50%). In addition, more than 90% of the epidemic strains separated from the clinical sample have different drug resistances, which have brought about many difficulties for the clinical treatment of dysentery patients. The continuously high incidence of dysentery has caused great losses to our national economy and seriously influenced the domestic people's health. How to effectively prevent bacillary dysentery has become a challenge before all medical workers especially for satisfying the needs of our country's development of the western regions.A lot of epidemiological statistical data indicate that the dominant strain of the Bacillus dysenteries prevalent in our country is Shigellae flexneri 2a 301 strain. The previous studies about Shigellae are mainly concentrated in its virulence, metabolism pathway, regulation of gene expression, genetic materials transfer, the pathogenic change of host cells in vivo,...