| The effect of CsB-851, an active part of alcoholic extract of mycelium from Cordyceps sinensis (BerK.) Sacc., on arterial thrombus formation in vivo was investigated. The New Zealand white male rabbits were randomly divided into three groups. Group A consisted of six rabbits infused with CsB-851 in a dosage of 30ug/Kg/min; Group B, six rabbits, infused with CsB-851 in a dosage of 90ug/Kg/mln ; Group C, six rabbits as control, infused with normal saline. One hour after the beginning of infusion, autologus Cr-platelets were injected and 10cm of the abdominal aorta was de-endotheliazed with a balloon catheter. The rabbits were sacrificed one hour after deendotheliazation. The injured abdominal aorta and uninjured thoracic aorta were removed and labeled platelet number per gram dry weight of the tissue was determined. In the control group, the labeled platelet number /gm dry weight of injured aorta was about 7 times as great as that of uninjured aorta. The group A had a significantly lower labeled platelet number /gm dry weight of injured aorta (98.14±9.41×10~6 cpm) than the control (201.25±27.21×l0~6cpm). This indicated that CsB-851 could reduce platelet accumulation at the deendotheliazed... |
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