Dampness Constitution And Their Gene Expression Profiles

Objective:To excavate the related theories of phlegm-dampness constitution from Traditional Chinese Medicine theory,summarize contemporary research achievement and expatiate the theories of phlegm-dampness constitution and its application. To indicate the basic concept,formative factor,judgment standard,developmental tendency,regulating method of phlegm-dampness constitution,instruct the prevention,diagnosis and treatment of correlative disease,for example, apoplexy,vertigo,cephalalgia,thoracic obstruction and diabetes,and the health cultivation and rehabilitation of phlegm-dampness constitution. To explore the gene expression characteristic,analyze the related gene function,expatiate the molecule mechanism,establish gene expression profile,and ultimately realize the gene detection of phlegm-dampness constitution.Methods:By the methods of the traditional literature research and the contemporary literature analysis , we discuss the correlative theories of phlegm , dampness and phlegm-dampness constitution from origin to development,from connotation to extension. By summarizing the clinical experience , this paper discusses the application of phlegm-dampness constitution theory in preventing and curing disease. This subject uses Affymetrix Gene Chip Human Genome U133 plus-2 to explore the gene expression characteristic of phlegm-dampness constitution.Results:It has been a long time for the traditional literature of TCM to the cognition of phlegm,dampness and phlegm-dampness constitution. There are both close relation and differentiation among phlegm,dampness and phlegm-dampness constitution,and doctors of past dynasties have contribute for the formation,development and consummating of the phlegm-dampness constitution theories. From the research , we consider that phlegm-dampness constitution is one of the common types of constitution which is affected by congenital heredity,malnutrition,etc,and it can form certain body structure,physiological function and mental profile,and be prone to suffering from correlative diseases. Phlegm-dampness constitution can be regulated,which is the effective measure to prevent and cure correlative diseases.Examining gene expression profile of peripheral blood cells of five phlegm-dampness...