Kidney Up Network Drink Neuroimmunological Mechanism For Multiple Sclerosis Research

Multiple Sclerosis(MS) is chronic inflammatory and demyelinating disorder disease involving white matter with the numerous affected areas of central nervous system possibly due to autoimmunity. The patients subjected to multiple sclerosis typically show alternating relapse and remission in the early stage of illness. MS is the one of the leading causes of neurological disability in young adults. It is regarded as stubborn disease. Producing the characteristic plaques or sclerosed areas that are the hallmark of the disease, MS has the serious effect to patient's living quality because of irreversibility nervous functional impairment. The disease incidence of MS is much more higher in Northern Europe and North America than Africa and oriental area. With the unceasing improvement of diagnosis instrument, the disease incidence of MS recently shows a ascending tendency obviously in China.On the basis of the overview to pathogenesy and treatment of Traditional Chinese Medicine(TCM) and Western medicine for MS, MS pathogenesy is approached at the point of view on TCM. From the aspects of pathogenesis and pathological changes localization, we interpret the basic pathogenesis characteristic that is brain marrow and collateral injury due to deficiency of kidney-essence, function disharmony of entrails, recurrence of exogenous evil, and the direction to treatment according to tonifying kidney, removing toxic substance, removing obstruction in collaterals.On the basis of the feature of compatibility and efficacy of the distinguished ancient prescription-dihuang yin, we bring forward Yi Shen Da Luo Decoction as the treantment prescription to MS, and carry out initial empirical study of its animal models- experimental allergic encephalomyelitis (EAE).This research was consisted of two parts: Discussion on the theory of pathogeny and pathogenesis of Multiple Sclerosis;The empirical study on EAE mouse.Part one Discussion on the theory of pathogeny and pathogenesis of MSFrom the view of TCM, the pathologic mechanism of MS was discussed encircling pathogeny and the course, in order to explain the pathologic mechanism change combined with characteristic in different phase of MS. With the connection of zang-fu viscera and channel, we put forward the pathogenesis theory. On the basis of insufficiency of kidney essence and function disharmony of entrails, turbid dampness and toxin accumulated, Governor Channel was impaired by pathogenic factors and brain marrow was slayed with injury in collaterals and marrow.