Clinical Study Of The Deficiency Of Kidney-Qi And Yin (Blood)Syndrome In Patients With Chronic Kidney Disease-3Stage

Objective To explore the characteristics of the syndrome of deficiency of Kidney-Qiand Yin (Blood) which can also be recognized as the syndrome of kidney, in patients with Chronic kidney disease-3stage(CKD-3stage). approach the relationship between the clinical manifestations and renal pathology with it, and observe the effect of the TCM treating patients with CKD-3stage.Methodsâ‘ To investigate the correlation between the score of the deficiency syndrome and the clinical and chemical index, by observing the distribution and the characteristics with the deficiency syndrome in the period of CKD3.â‘¡To analyze the relationship between the score of the deficiency syndrome and renal pathology in CKD-3stage patients.â‘¢To randomize187patients into three groups including TCM group.ACEl group and TCM integrated with ACEI group which being treated with TCM decoction,benazepril and combtination of two medcines respectively. Observe the changes in the syndrome scores and indices from the laboratory, after24weeks' treatment.Resultsâ‘ 95.15%of the patients with CKD-3stage have deficiency syndrome, meanwhile88.98%of the patients have the deficiency syndrome together with wind-dampness syndrome and/or blood stasis syndrome; the patients with deficiency syndrome have a higher level in the24h proteinuria. serum creatinine. and oppositely a lower level in eGFR compared with the patients in non-deficiency syndrome. The patients with multiple syndrome have a higher level in24hour urine quantitative protein. serum creatinine than the patients in isolated deficiency syndrome. Conversely, they exhibited a lower level in eGFR and plasma albumin, compared with the isolated decifiency patients.â‘¡The patients who have seriously deficiency syndrome have higher score in pathological total score (katafuchi score), Glomerular sclerosis score(Andreoli score) and cellular crescentic's score. The patients who have two or three syndromes have higher score in many aspects, including activity index total scores Interstitial inflammatory cell score,chronicity index totalscore and fiber crescentic score (Andreoli score) than the isolated deficiency patients.â‘¢All of the three groups make benefit to the syndrome total score, but TCM group and the combination of TCM and ACEI is superior to ACEI group;the amount of urinary protein in the the combination of TCM and ACEI decreased obviously than before;the eGFR level of the TCM group and the combination of TCM and ACEI group rise obviously after the treatment;Similarly, hemoglobin is improved in the TCM group.the results all have statistically significant.Conclusionâ‘ Deficiency syndrome is the main syndrome in the CKD-3stage, it always exists with blood stasis or/and wind-dampness syndrome. the severity of deficiency syndrome and the combination of syndromes are closely related to urinary protein excretion and renal function.â‘¡The severity of deficiency syndrome is related to the chronicity index of the renal pathology, and proves more varieties of manifestations in chronic and acute disease.â‘¢Traditional Chinese medicine is proven to have an excellent curative effect in lightening the symptoms of the deficiency syndrome and protecting renal function. and if it is used in combination with ACEI, a much better efficacy can be achieved.