Distribution Of Windpathogen In Chronic Primary Glomerular Disease And Correlation Between Windpathogen And Inflammatory Factor

Chronic primary glomerular disease is a kind of prevalent kidney disease, and is the main cause of the end stage renal disease (ESRD) in China. Chinese medicine treatment has a great advantage in delaying the development of chronic kidney disease. Many researchers have discussed the treatment of chronic primary glomerular disease based on the theory of wind. However, differences exist in the status of wind in kidney disease. Previous studies have focused on clinical theory and personal experience, which lacks specific study on objective syndrome, indicators and pathogenic mechanisms.Objective:To observe the differences of clinical symptoms, syndromic types and pathological types between the windpathogen group and non-windpathogen group. To determine whether chronic kidney disease is associated with windpathogen by analyzing the difference of many factors including symptoms,physical signs, blood pressure,blood biochemical indexes,blood and urine routine,24hupro, CRP,renal pathology,TNF-α and IL-6in both blood and urine.Methods:Test1included128patients. Clinical data was collected to explore the relationship between pathogenic wind syndrome and other TCM syndromes, and the characteristics of pathogenic wind in chronic primary glomerular disease.106patients were brought into the investigation in test2. Col lected serum and urine samples of40patients, used ELISA method to measure the levels of serum and urine IL-6, TNF-alpha, and SPSS18.0to analyze the data.Results:1Pathogenic wind syndrome is the most common syndrome (60.7%) in patients with chronic kidney disease. The most common symptoms in windpathogen patients include foamy urine (56.25%), puff iness of face (53.13%) and repeated at tack by exopathy (50.78%)2Pathogenic wind syndrome was often mixed with dampness-heat syndrome (27.34%) in excess pathogenic factors. Windpathogen exists extensively in various pathological types and in CKD1-4.3The quantitative of proteinuria in24hour was significantly increased in windpathogen group, and serum albumin was decreased significantly. The amount of patients who have wind syndrome increased as24hour urinary protein increased.4The level of IL-6,TNF-α in serum and urine of patients with chronic primary glomerular disease were significantly higher than the healthy control group (P<0.05); urine TNF-α levels in patients of CKD4were significantly higher than CKD2period.5The level of IL-6in serum of patients with pathogenic wind syndrome was significant ly higher than the non-windpathogen group (P<0.05). The level of TNF-α in urine of patients with pathogenic wind syndrome was significantly higher than the non-windpathogen group (P<0.05). No difference exist both in serum TNF-α and in urine IL-6between the patients with pathogenic wind syndrome and non-windpathogen group (P>0.05)Conclusion:(1) TCM syndrome type differences exist in patients with chronic kidney disease. Pathogenic wind syndrome is the most common syndrome in patients with chronic kidney disease. The most common symptoms in windpathogen patients include foamy urine, puffiness of face and repeated attack by exopathy. Pathogenic wind syndrome was often mixed with dampness-heat syndrome.(2) The quantitative of proteinuria in24hour was significantly increased in windpathogen group, and serum albumin was decreased significantly. The amount of patients increased as24hour urinary protein increased.(3) The level of IL-6,TNF-α in serum and urine of patients with chronic primary glomerular disease were significantly higher than the healthy control group (P<0.05); The level of IL-6in serum of patients with pathogenic wind syndrome was significant ly higher than the non-windpathogen group (P<0.05). The level of TNF-α in urine of patients with pathogenic wind syndrome was significantly higher than the non-windpathogen group (P<0.05).