Study On Effect And Mechanism Of Simotang In The Treatment Of Liver-Qi Stagnation IBS-C

Objectives1Observe the clinical symptoms of IBS-C. Evaluate the curative effect of Simo decoction on Stagnation of liver-Qi stagnationof IBS-C.2Establish rat model of Stagnation of liver-Qi stagnation of IBS-C, Observe their changes in synaptic plasticity,synaptophysin,neurotransmitter,.Probe into the Function Mechanism of Simo decoction treat on Stagnation of liver-Qi stagnation of IBS-CMethods1Clinical researchGrouping158cases of Stagnation of liver-Qi stagnationof IBS-C patients into two parts,one were treat with Simo decoction,other Mosapride,Observe the clinical symptoms of IBS-C patients;Evaluate the curative effect of Simo decoction on Stagnation of liver-Qi stagnation of IBS-C.Filling out questionnaires before and after treating.Evaluate the curative effect of Simo decoction and Mosapride.2Animal experimentGrouping60SD rats into six parts.Put5of them int Stagnation of liver-Qi stagnation of IBS-C model,by the way of cliping tails and eating disorders Normal group fed conventionally,TCM-groups were intragastric infusion with Simo decoction6ml/kg,12ml/kg,24ml/kg,7days. Observe thier changes in synaptic plasticity,synaptophysin,neurotransmitter.Results1Clinical research Simo decoction helping patients with Stagnation of liver-Qi stagnation of IBS-C to alleviate symptoms.The difference between Simo decoction and Mosapride determined was statistically significant (P<0.05) 2Experimental research2.1Simo decoction helping Rats with Stagnation of liver-Qi stagnation of IBS-C to alleviate symptoms.The difference between Simo decoction and Mosapride determined was statistically significant (P<0.05)2.2The synaptic plasticity of the colon of Liver-Qi stasis model rat had changed,Simo decoction helping Rats with Stagnation of liver-Qi stagnation of IBS-C to repair. The difference between Simo decoction and Mosapride determined was statistically significant (P<0.05)2.3The difference of the neurotransmitters of six groups rats was statistically significant.Simo decoction helping Rats with Stagnation of liver-Qi stagnation of IBS-C to getting more normal.The difference between Simo decoction and Mosapride determined was statistically significantConclusion1Simo decoction helping patients with Stagnation of liver-Qi stagnation of IBS-C to alleviate symptoms.2Simo decoction can speeding the gastric emptying and small intestine propulsion of rats with Stagnation of liver-Qi stagnation of IBS-C.3Simo decoction helping Rats with Stagnation of liver-Qi stagnation of IBS-C to repair the synaptic plasticity.4Simo decoction helping the neurotransmitters of rats with Stagnation of liver-Qi stagnation of IBS-C to getting more normal.5The key point of Simo decoction to treat IBS-C may be to repair the synaptic plasticity...