Correlation Of The Polymorphisms Of HLA-A, B And DRB1 Alleles With The Susceptibility To Lung Carcinoma

Objective: To investigate differences of HLA-A, B and DRB1 alleles among lung carcinoma patients and healthy controls, in order to determine the correlation between genetic susceptibility to lung carcinoma of Han nationality from North China and the polymorphisms of HLA-A,B and DRB1.Methods: The polymorphisms of HLA-A, B and DRB1 alleles in 140 unrelated patients with lung carcinoma and 483 unrelated normal controls of Han nationality from North China were examined using sequence-based typing(SBT)and polymerase chain reaction with sequence-specific primer(PCR-SSP).Results: The frequencies of HLA-A*26:01, HLA-B*15:18, HLA-B*38:02, HLA-DRB1*04:01, HLA-DRB1*04:02 and HLA-DRB1*12:01 were higher in the lung carcinoma group than those in the normal control group, with P values were respectively 0.021,0.001,0.015,0.021,0.010 and 0.046, while OR values were respectively 3.513,3.842,2.715,3.512,13.986 and 1.828. The frequencies of HLA-DRB1*10:01 and HLA-DRB1*13:02 were lower in the lung carcinoma group than those in the normal control group, with P values were respectively 0.017 and 0.014, while OR values were respectively 0.135 and 0.122. The frequencies of haplotype HLA-A*02:07-B*46:01-DRB1*09:01 and HLA-A*02:06-B*51:01 were higher in the lung carcinoma group than those in the normal control group, with P values were respectively 0.034 and 0.006, while OR values were respectively 2.348 and 3.969. The frequency of haplotype HLA-A*11:01-DRB1*15:01 was lower in the lung carcinoma group than those in the normal control group, with P value was 0.026 and OR was 0.146. The frequency of haplotype HLA-A*01:01-B*37:01 was 0.02070 but not found in lung carcinoma group.Conclusion: The frequencies of some HLA alleles(HLA-A*26:01, HLA-B*15:18, HLA-B*38:02, HLA-DRB1*04:01, HLA-DRB1*04:02, HLA-DRB1*12:01, HLA-DRB1*10:01 and HLA-DRB1*13:02 ) and haplotypes( HLA-A*02:07-B*46:01-DRB1*09:01, HLA-A*02:06-B*51:01 and HLA-A*11:01-DRB1*15:01)maybe related with the susceptibility to lung carcinoma of Han nationality from North China.