Hou Pathogenesis Of Hypertension And Hypertension And Sugar Metabolic Abnormalities In Patients With Tcm Syndrome And Experimental Research

Objective This study follows the methods and principles of clinical epidemiology, medical treatment since the Beijing Dongzhimen Hospital in elderly hypertensive patients based on clinical data, and explore hypertensive patients with abnormal glucose metabolism and biological Syndrome Characteristics.Methods Collected from April 2009 to March 2011, to Dongzhimen Hospital of cardiovascular and cardiovascular outpatient medical ward patients with primary hypertension, the clinical epidemiology of randomized, controlled, cross-sectional cohort study Using the chi-square test, rank sum test, t test and logistic regression analysis to study hypertension and abnormal glucose metabolism in patients with hypertensive syndromes level changes and changes in physical and chemical indicators, and explore the multiple risk factors clustering on TCM Climate performance. Appli cat ions in 2005《China's hyper tens ion guidelines (Revised Edition)",1986 "Chinese deficiency syndrome reference standard",1986, "blood stasis syndrome diagnostic criteria, " and the 1995 "People's Republic of industry standards·dizziness standards " Standards and guidelines of disease and syndrome, while the biological tests by laboratory studies, including high-sensitivity C-reactive protein (Hs-CRP), oxidized low density lipoprotein (OX-LDL) leukocyte platelet aggregation in whole blood (whole blood PAgT) And plasma platelet aggregation test (plasma PAgT), interleukin-6 (IL-6), serum neuron-specific enolase (NSE) and matrix metalloproteinase-9 (MMP-9) a total of seven laboratory parameters, Collected by questionnaire survey of patients with multiple risk factors and associated syndromes, selected from the age of 30 to 85 years of age in 172 cases of elderly patients, focusing on the process susceptible to hypertension multiple risk factors clustering features of hypertension Disease and abnormal glucose metabolism in hypertensive disease syndromes and its biological characteristics.Results①Hypertension and abnormal glucose metabolism group and the hypertension syndrome distribution group to permit more common blood stasis, and a guilty conscience.②Hypertension and abnormal glucose metabolism group and the hypertension group gathered in the multiple risk factors in different states, and in some TCM objective conditions, some physical and chemical indicators of the two groups were significantly different levels:hypertension and blood glucose Abnormal performance in a subgroup of the wind permits high sensitivity C-reactive protein (Hs-CRP) and oxidized low density lipoprotein (OX-LDL) levels rose significantly higher than hypertension; Qi deficiency hypertension and abnormal blood sugar the whole Increased blood levels were significantly higher than Pagt simple hypertension.③Physical and chemical indicators for hypertensive patients with the TCM pathogenesis of the logistic regression analysis, found that white blood cells in whole blood platelet aggregation test (whole blood PAgT) of blood stasis and pathogenesis, serum neuron-specific enolase (NSE) and Platelet aggregation in whole blood leukocytes (whole blood PAgT) of wind syndrome pathogenesis, oxidized low density lipoprotein (OX-LDL) on the pathogenesis of Qi deficiency had significant influence.④In the comprehensive statistical analysis of TCM Pathogenesis and more the focus of cerebral vascular disease risk factors, the heat of the pathogenesis of wind syndrome pathogenesis have significant impact; liver deficiency and pathogenesis of this on the air permits and pathogenesis of the formation of no significant Statistical effect, but when the wind permits pathogenesis adding no significant effect on the same fixity of pain and vascular abnormalities statistical variables, it has had on the generation of wind syndrome pathogenesis statistically significant effect.Conclusion①Most of the blood of patients with hypertension hypercoagulable state exists, and with the progress of the disease, there is more to permit a guilty conscience, suggesting that we should try to use blood circulation method.②Patients with hypertension and abnormal glucose metabolism in the pathogenesis of the wind conditions permit the inflammatory response in vivo in patients with hypertension is more severe than the simple; patients with hypertension and abnormal glucose metabolism in the pathogenesis of Qi deficiency of blood coagulation under the conditions of the body to More than simply high blood pressure patients, indicating that hypertension and abnormal glucose metabolism in patients with the severity of blood stasis in vivo than simple hypertension.③Some physical and chemical indicators of hypertension syndromes of their significant influence platelet aggregation in whole blood leukocytes (whole blood PAgT) of blood stasis and pathogenesis, serum neuron-specific enolase (NSE) and whole blood Leukocyte platelet aggregation test (whole blood PAgT) of wind syndrome pathogenesis, oxidized low density lipoprotein (OX-LDL) on the pathogenesis of Qi deficiency had significant influence, which extended our micro-TCM provides an experimental basis for differentiation, And oxidized low density lipoprotein (OX-LDL) on the pathogenesis of Qi deficiency also significantly affect the theory of Qi and stroke provides an experimental basis. This shows the classic TCM diagnosis and the combination of modern disease diagnosis can significantly improve the diagnostic accuracy levels, improve the clinical diagnosis of the disease is inseparable from the development of modern life sciences, but must not neglect the participation of the classic study of TCM.④There are two ways the production of drugs, one is single Xie Sheng that can cause poisoning, and the other way as the aggregation of risk factors in patients, may originally on the "poisonous " have no effect or little effect Factors together was able to "poison"and produce a significant effect.