Empirical Study On Complex Prescription Tripterygium Wilfordii Decoction Attenuation Synergistic Action In Degenerative Nephritis Rat

Complex prescription Tripterygium wilfordii decoction on nephroticsyndrome interfere in object, on account of traditional Chinese medicinecompatibility theory and modern pathology and toxicology recognitionselect Chinese crude drug organize prescription. Tripterygium wilfordiiis principal drug onprescription, compatibility Polygonum multiflorum,astragali, angelica, christina loosestrife and licorice root five possessmutual detoxication between two drugs,assistant to aid restrict,fivepossess neutralizepoison,attemper and strengthening body resistancecontribution, furthermore is able to preserve Tripterygium wilfordiinoxious property target aim to traditional Chinese medicine, aim atdegrade Tripterygium wilfordii noxious property, boost its curativeeffect, checkout compare systematic estimate, set up draw assistance fromcompatibility to come true Attenuation synergetic thinking with method.objective: (1) set up compatible traditional Chinese medicinecompatibility theory and modern pathology toxicology cognition for cometrue contain noxious property Chinese crude drug diminutive complexprescription Attenuation synergetic select drug organize prescriptionmethod; (2) establish contain noxious property traditional Chinesemedicine diminutive complex prescription poison potency relationappraise method; (3) on account of experiment bolting to cure nephroticsyndrome contain noxious property traditional Chinese medicineTripterygium wilfordii poison potency relation optimizing thetraditional Chinese medicine diminutive complex prescription.Method: adopt domestic overseas generally acknowledged rats venacaudalis injection Adriamycin, reproduce minimal change nephroticsyndrome supply complex prescription Tripterygium wilfordii decoctioncum its break prescription deal, by means of prednisone make positivecontrol, detect body weight 24 hour Urine protein,whole blood,totalprotein,albumen,cholesterin,glycerine three sulfatide,Crea,ureanitrogen,glutamate-pyruvate transaminase,aspartate aminotransferase,creatine kinase,creatine kinase isoenzyme, heart,liver,kidneylightmicroscope,electron microscope. To observe Tripterygium wilfordiidifferent compatibility effect on heart,liver,kidney Attenuation synergia.Result: lei wu group,lei gui group,whole prescription group,lei jin group with Tripterygium wilfordii mock-up group rats body weightwith statistics comparison P＜0.05, possess statistical significance,whole prescription group,lei qi group,lei cao group with Tripterygiumwilfordii mock-up group rat degrade 24 hour Urine protein with statisticscomparison P＜0.05, possess statistical significance, whole prescrip-tion group,lei qi group,lei cao group with Tripterygium wilfordii mock-upgroup rat heighten total protein albumen degrade cholesterol glycerinethree grease compare P＜0.05, have statistical significance, wholeprescription group,lei cao group,lei jin group,lei gui group wtihTripterygium wilfordii mock-up group rat urea nitrogen,creat withstatistics comparison P＜0.05, possess statistical significance, wholeprescription group,lei cao group,lei wu group wtih Tripterygiumwilfordii mock-up group rat aspartate aminotransferase,glutamicpyruvic transaminase compare P＜0.05, possess statistical significance,whole prescription group, lei cao group, lei wu group lei jin group,lei gui group with Tripterygium wilfordii mock-up group rat creatinekinase,creatine kinase isoenzyme with statistics comparison P＜0.05,possess statistical significance, whole prescription group,lei caogroup,lei wu group,lei qi group,lei jin group,lei gui group withTripterygium wilfordii mock-up group rat white cell,blood disc withstatistics comparison P＜0.05, possess statistical significance,mock-up blank group with normal blank group CK,CK-MB with statisticscomparison P＜0.05, possess statistical significance, mock-up blankgroup with normal blank group white cell,blood disc with statisticscomparison P＜0.05, possess statistical significance, Tripterygiumwilfordii mock-up group with mock-up blank group urea,crea withstatistics comparison P＜0.05, possess statistical significance, normalTripterygium wilfordii group with normal blank group urea nitrogen,creat with statistics comparison P＜0.05, possess statistical signify-cance, Tripterygium wilfordii mock-up group with mock-up blank groupaspartate aminotransferase,glutamic pyruvic transaminase withstatistics comparison P＜0.05, possess statistical significance, normalTripterygium wilfordii group with normal blank group aspartateaminotransferase,glutamic pyruvic transaminase with statisticscomparison P＜0.05, possess statistical significance, Tripterygiumwilfordii mock-up group with mock-up blank group creatine kinase creatinekinase Isoenz with statistics comparison P＜0.05, possess statisticalsignificance, normal blank group with normal Tripterygium wilfordii group creatine kinase Isoenz with statistics comparison P＜0.05, possessstatistical significance, Tripterygium wilfordii mock-up group withmock-up blank group white cell,blood disc with statistics comparisonP＜0.05, possess statistical significance, normal Tripterygium wilfordiigroup with normal blank group white cell,blood disc with statisticscomparison P＜0.05, possess statistical significance, light microscope,electron microscope result to show: Tripterygium wilfordii differentcompatibility group in heart,liver,nephric histomorphology,finestructure compare control group pathological lesion have different levelmitigation.conclusion: idriamycin make degenerative nephritis mock-up issucceed, degenerative nephritis rat body weight descend, Tripterygiumwilfordii and its different compatibility, group, post-treatmentdegenerative nephritis rat body weight go up. illustrate lei wu group,lei gui group whole prescription group,lei jin group all have heightendegenerative nephritis rat body weight synergistic action. Tripterygiumwilfordii and its different compatibility group cut down rat 24 hour Urineprotein therapeutic action, whole prescription group,lei qi group,leicao group for degrade rat 24 hour Urine protein have synergistic action.Tripterygium wilfordii and its different compatibility group forheighten rat blood plasma total protein,albumen, degrade cholesterol,riglyceride have therapeutic action, whole prescription group,lei qigroup,lei cao group for heighten rat blood plasma total protein,albumen, degrade cholesterol,riglyceride have therapeutic action. wholeprescription group,lei cao group,lei qi group,lei gui group have reduceTripterygium wilfordii nephrotoxicity toxic effect. whole prescriptiongroup,lei cao group,lei wu group reduce Tripterygium wilfordii Hepaticnoxious property. Tripterygium wilfordii different compatibility groupall can against Tripterygium wilfordii the heart noxious property, amongthe total whole prescription group and lei wu group,lei qi group,leicao group better than lei gui group,lei jin group. Tripterygium wilfordiidifferent compatibility group all can against Tripterygium wilfordihematological system noxious property among the total whole prescriptiongroup and lei wu group,lei jin group better than lei qi group,lei guigroup,lei cao group. Adriamycin make egenerative nephritis mock-up havetoxic action to rat the heart hematological system. Tripterygiumwilfordii On physiological functions condition long-term use havenephrotoxicity,the heart noxious property,hepatotoxicity,cut down whitecell,blood disc effect, digestive system side effect. Tripterygiumwilfordii On pathologic state long-term use have nephrotoxicity,the heart noxious property,hepatotoxicity,cut down white cell,blood disceffect, digestive system side effect. Tripterygium wilfordii complexprescription compatibility can have Attenuation synergistic action.