The Experimental Study On Coptidis Rhicoptidis Total Alkaloids Efferescent Tablet Treating Ureaplasma Urealyticum Infection Of Feamle GENITALi

This paper based in clinical and academic thought of tutor professor Xiuxia Wang in diagnosing and treating Ureaplasma urelyticum,UU infection in female hyp-genital duct.we used Coptis total alkaloids effervescent which was studyed and exploited independently by us to research how to treat the infection of UU in the female genital tract[FGT],to research clinical effect and mechanism of action , introduced the traditional Chinese medicine name and pathogenic mechanism of this disease systemly, and indicated the science evidence of treating the disease with Coptis total alkaloids effervescent according to this foundament.In clinical we use positive control medicine research in random,the result cheating rate is 50%,effecting rate is 60%,total effecting rate is 80%,the same with Ciprofloxacin group.firstly proved by experiment research:the low concentration of Coptis total alkaloids effervescent inhibition UU in vitro is 0.2-0.6 mg/ml, MIC₅₀ is 0.4mg/ml, MIC₉₀ is 1.6mg/ml.We approach the traditional Chinese medicine effect with Balb/c mouse genital duct infected UU animal model fistly,prove that Coptis total alkaloids's adherence effect to inhibite rabbit ovarian mucosa epithelial cell ex vitro, in the meantime decrease UU's cell damage,and inhibite UU's cell toxic with human cervical carcinoma epithelial cell and protect cell proliferation, inhibite apoptosis. It provide science evidence for traditional Chinese medicine treating the disease in future, establish the foundation for supplying traditional Chinese new medicine treating this disease , its sense is perspective for academic and social economic.