| Intervntional neuroradiology had developed in 1970s from luessenhop indroduced the concept of endoarterial embolization of cerebral AVMs with the patriculate agents by catheters in the 1960. The development of the new technique accelerated in the 1980s through the clinical use of DSA and new microcathethers. To date, the greatest successes have been achieved in the thesapy of three directions; a) making some vascular lesions that were once inoperable amenable to surgical cure. and to have a good end results; b) replacing some operations with simple therapy and enhancing therapeutic results; c)preoperative embolization treatment of vascular neoplasms of the head and neck to make preparation for radical operation by reducing hemorrhage during operation.A research into the technical and material selection for embolization is very importent to achieve success of endovascular treatment. Therefore the studies were based on the two directions: a) widely carring out the clinical treatment of endovascular embolization and improving the techniques of embolization; b)comparing several embolic agents with the pathology and clinical results by animal experimental and clinical experience to regard as a basis selecting the agent.In the present study, 24 rabbits were randomized for four groups. Embolic effects and pathology were evaluated during selective cerebral angiography and four kinds of embolic agents including IBCA(France), N-TH adhesive (Xian), silk microparticle and surgical silk suture were injected respectively through a catheterization in the common carotid of rabbits under DSA fluoroscopy.A model of endovascular embolization of rabbit head was established, which could observe clearly at that time effecte and morphological changes after embolization in the experimental study, The results of embolic agents show then embolic effects of IBCA or N-TH were reliable and their reactions were also... |
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