Alterations And Significance Of Calmodulin, Lipid Mediators And Lactic Acid Content In Blood And CSF During Severe Head Injury

This study, consisting of three parts, was designed to investigate the changes and significance of neuronal Ca²⁺ channel, lipid mediator and lactic acid content following brain injury. The first part being an animal experiment, and the second and third parts clinical trials.Part I: Alterations of lipid mediators ( thromboxane A2 and prostacyclin ) and effects of ligustrazini hydrochlrioi after rat head injuryOne hundred and ten male Wistar rats were used to make a model of head injury with a weight drop device; thromboxane B2 (TXB2) and 6-keto-prostaglandin F1 a(6-keto) content in damaged cerebral tissue and serum was measured at 5, 15, 60, and 180 minutes after injury by RIA. Morever, Evans blue staining in cortical tissue and tight and electron...