Quantitative Detection Of The CagA Of Helicobacter Pylori And The Practical Study Of Its Expression Products

Helicobacter pylori (Hp) plays an important role in the upper digestive tract diseases. It is the pathogenic bacterium of chronic active gastritis, the main factor causing peptic ulcer, and the cofacter of gastric carcinogen. Hp can be divided into two main groups (toxic and non-toxic Hp) according to the production of Vacuolating cytotoxin (VacA). The toxic bacterium also contains cytotoxin associated protein A gene (cagA) and synthesizes the protein (CagA) which might have something to do with the transcription, folding, transportation and the function of VacA. Studies show that cagA positive Hp(cagA~+Hp) accounts for more than 50% of all kinds...