Structural Basis For Translocation Between Cytoplasm And Nucleus And Molecular Mechanism For Initiation Function Of Cell Apoptosis Of The BRD7 Protien

BRD7 is a novel bromodomain gene cloned by cDNA representational differential assay and encodes a bromodomain protein. The overexpressed BRD7 could inhibit the proliferation of nasopharyngeal carcinoma (NPC) cells and arrest them in G0/G1 phase by transcriptionally regulating some important molecules involved in ras/MEK/ERK and Rb/E2F pathways. It was found that BRD7 could down-regulate the promoter activity of E2F3 and interact with nuclear transcription factor IRF2 and adenovirus nuclear protein E1B-AP5 to affect their transcription activity. These suggested that BRD7 is a potential nuclear transcription regulator. BRD2 (Ring 3), a putative interacting proteins of BRD7, was screened from human fetal brain cDNA library by yeast two hybrid system. It is a cell cycle dependent...