CRH Involved In The Inflammatory Pain And Electro-Acupuncture Analgesia And Immunoregulation In AA Rats

The main characteristics of stress response are a series of physiological and psychological changes from activation of hypothalamus-pituitary-adrenal (HPA) axis. It is very complicated to control the activation of HPA axis in central nervous system. Synthesis and release of corticotropin-releasing hormone (CRH) from hypothalamus plays a key role in the regulation of the HPA axis. CRH controls the stimulating level of HPA axis. CRH and CRH-R1 receptor are distributed widely in central nervous system, and have been shown to play a role in lots of physiological functions, such as pain modulation,endocrine and immune response.In the inflammatory pain rat model,the previous studys showed that i.t. CRH inhibited acetic acid injection-induced hyperalgesia,and direct influence on immunological function has been discovered recently.Inflammatory pain is common disease in clinics. Substantial evidences have indicated that electro-acupuncture (EA) is an effective method for analgesia and has been used in clinics. EA plays its analgesic role via activating the endogenous pain modulating systems, including endogenetic opioid and serotonin descending system. Traditional Chinese medicine considers that acupuncture can raise the healthy tendency of the organism and eliminate the sick tendency. According to modern medicine, acupuncture can strengthen the immune system of the organism. The role of CRH playing in EA analgesia and immunity in inflammatory pain is still unclear.Therefore the aim of the present study was designed to investigate the effects of...