| Epilepsy is a group of chronic disease characterized by recurrent episodic central nervous system dysfunction caused by abnormal discharge of neurons. It is one of the most common neurological disorders, which affects about 0.5%-1% people worldwide. At present, studies on pathogenesis and treatments of epilepsy made progress, however, approximately one third epileptic patients still develop intractable epilepsy. Temporal lobe epilepsy (TLE) is one of intractable epileptic syndromes and is the focus, of researchers' attention on intractable epilepsy in the recent more than ten years. 40% of TLE are acquired, meaning that the epileptic condition is acquired through an injury to the centralnervous system ( CNS ) . Neuronal injury such as status epilepticus (SE), stroke, and traumatic brain injury produces long-term plasticity... |