Studies On The Chemical Constituents Of Three Strains Of Polyporaceous Fungus, Fomes Cajanderi, Fuscoporia Obliqua And Phellinus Yamanoi

Many strains of polyporaceae have been used as folk medicine for the treatment of coldphegm, relieving cough and asthma, including diuresis and excreting dampness, detoxicating and antitumor etc. In order to investigate their effective constituents and find new active compouds, chemical studies were systemmatically carried out on Forties cajanderi Karst, Fuscoporia obliqua Fr. Te. Lát and Phellinus yamanoi (Imaz.)Shaw.Twenty eight compounds were isolated from the mycelium of Fomes cajanderi. From which, the structures of twenty-four were elucidated by chemical, spectral methods and X-ray crystallographic analysis, as: ergosterol (1), fomecajanderic acid A (3-oxy-26-eburicoic acid) (2), fomecajan-deric acid B(3-oxy-16 α -acetoxypachymic acid) (3),ergosta-4,6,8(14),22-tetraen-3-one (4),ergosterol peroxide (5),fomecajanderi acid C(3 α -acetoxy-23-oxy-24-methyl-lanosta-8-en-26-oic acid) (6),methyl fomecajanderate A(methyl 3-oxy-26-eburicate) (7),methyl fomecajanderate B(methyl 3 α-acetoxy-23-oxy-24-methyl-lanosta-8-en-26-ate) (8), methyl fomecajanderate C(methyl 3 α -acetoxy-23-oxy-26-eburicate) (9),fomlactone A (10),fomlactone D (11),ergosta-7,22-dien-3 β -ol (12),fomlactone B (13),fomlatone E (14),fomlactone F (15),dimethyl carboxyacetylquercinate A(16),methyl fomecajanderate D(methyl 3,23-dioxy-31-chloromethyllanosta-8-en-26-ate (17), dimethyl carboxyacetylquercinate B( 18),methyl fomecajanderate E [methyl 23-oxy-3 α-(2-carboxymethyl-acetoxy)-31-methoxy-lanosta-8-en-26-ate] (19),fomlactone C (20),methyl fomecajanderate F(methyl 23-oxy-3 α ,24-janderat J(methyl-3 β -acetoxy-26-eburicate) (22), fomlactone G (23) and mannitol (24). except for compounds 1,4,5,6,8,12,16,18 and 24 were the first isolated from this fungus, others were new compouds and compounds 17,19...