The Role Of Insulin Resistance In The Clustering Of Cardiovascular Risk Factors In A Population With Relatively Low Mean Body Mass Index And Serum Cholesterol

Coexistence of multiple cardiovascular risk factors in the same individual is now known to be associated with greatly increased risk of cardiovascular disease. Recent studies have shown that the phenomenon, now called clustering of cardiovascular risk factors, occurs more often than would be expected by chance , but whether there is a common etiologic factor underlying the phenomenon is not clear. Evidence from some basic and clinical research has indicated that insulin resistance is associated with hypertension, dyslipidemia, obesity, and glucose intolerance and might be the common link among these risk factors, thus playing a key role in the clustering of cardiovascular risk factors. However, available knowledge about the relationship of insulin resistance to cardiovascular risk factors is controversial and based primarily on data from Western populations, which are generally obese and mainly of European origin. Direct epidemiological evidence on the insulin resistance and clustering of cardiovascular risk factors is extremely scarce and urgently needed, especially in a relatively lean population.Purposes of Study:To understand the relationship of insulin resistance to hypertension, hypertriglyceridemia, low level of high-density lipoprotein cholesterol,...