| It has been demonstrated that the obstructive sleep apnea (OSA) has increased the cardiovascular morbidity and mortality, such as stroke and myocardial infarction, and that about 50-90% OSA patients were with hypertension (HT) and over one third hypertensive patient with OSA. Recent controlled studies suggest that potential confounders such as obesity, age and insulin resistance cannot fully explain this association. It has been also demonstrated that the role of genetics is more and more important in the etiology of OSA. OSA, therefore, seems to be an issue of concern for clinicians and researchers in the hypertension field.We designed the project to investigate the influence of blood pressure variability on and the effects of antihypertensive medication on hypertension. To study the ACE gene I/D polymorphism in the patients with OSA elucidated the mechanism and interaction between OSA and cardiovascular diseases on the level of clinic and molecular.Obstructive sleep apnea is a common condition characterised by repetitive partial or complete interruption of air flow and oxygen desaturation during sleep. During a typical apnea ventilation cycle there are vigorous attempts to breathe against an occluded airway during the apnea followed by arousal and heavy snoring as airflow is restored. Apnea exerts several acute cardiothoracic, neural and hemodynamic effects and the blood pressure initially may fall during apnea, subsequently it rises. The fall in blood pressure over 10% during the night compares with the day consists both of a reduction in physical activity lowering blood pressure to baseline and a subsequent fall in that baseline with sleep in normal population. The part of hypertensives and OSA patients, however, do not have this blood pressure change during night. It is called that these blood pressure profiles were dipper or non-dipper, respectively.The study presented three main findings: (1) There was a significant...
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