Injectable Engineering Heart Tissue Restore Myocardium Infarction In A Rat Model

Background Adult cardiomyocytes have a limited capacity to regenerate themselves, and damage to myocardium usually results in irreversible dysfunction. The most common phenomenon of cardiac dysfunction takes place as a result of myocardial ischemia and infarction (Mi). A significant loss of cardiomyocytes due to Ml usually leads to the development of progressive heart failure. So the development of new therapeutic strategies to deal with the situation becomes imperative. Cell transplantation as an innovative approach in the treatment of heart failure has been investigated for more than a decade. Promising results of clinical trials have been launched recently. The strategy, however, is limited. With a view to these critical obstacles, new advances in tissue engineering may provide innovative solutions for myocardial regeneration procedures. Beginning in 1997, Eschenhagen and Zimmermann mixed artificial extracellular matrix, mainly containing collagen type l and Matrigel with freshly isolated...