Study Of Biomarkers And Clinical Multivariate Analysis Of Prostate Cancer

In this study, we assessed the diagnostic utility of a 34βE12/α-methylacyl-CoA racemase(AMACR) antibody cocktail and compare the staining pattern it produces with that using the individual antibodies alone. We found that the sensitivity of AMACR using the cocktail was identical to that using the individual AMACR antibody. There was no correlation between AMACR staining and the Gleason sum and the operation modus of prostate cancer by either method. Using AMACR as a positive marker in association with 34βE12 as negative markers for immunohistochemical analysis can help to confirm the diagnosis of prostate cancer. A comprehensive retrospective analysis was performed to identify the significant markers in the diagnosis and differential diagnosis of PCa. And we found that AMACR, high molecular weight cytokeratin, PSA, f-PSA/t-PSA and PSAD are all efficient markers for the diagnosis of prostate cancer.