Small Animal Models Of Cardiac Arrest And Relative Factors Of Interfering Therapeutic Efficacy During Cardiopulmonary Resuscitation

Background and objectives:Due to interference of many factors in the clinical investigation, it is difficult to conduct a profound pathophysiologic study regarding cardiac arrest (CA) and cardiopulmonary resuscitation (CPR). An advantage of animal models in CPR research is the ability to control differing variables that may be impractical to standardize in clinical trials, which provides an opportunity to testify different kinds of medications and treatments involved in CA and CPR. A lot of similarities can be found between small animals, such as rabbit, rat, mouse and so on, and large animals even human being. Therefore, an increasing number of small animals have been used in CPR experimental study.To establish an animal model of CA is the key to conduct a CPR experimental study. Ventricular fibrillation is induced by alternating current delivered to right ventricular endocardium, which is the primary technique of establishment of animal model of CA in rat and in mouse currently. Unfortunately the manipulation is too difficult to practise in the most circumstance. One of the purposes of the study, therefore, is looking for more simple and convenient methods to establish an animal model of ventricular fibrillation in rat and in mouse.