| PREFACEBone marrow stem cells mobilization is a newly - developed non - invasive method to stimulate stem cells residing normally in bone marrow to peripheral blood using various cytokines. Across the broad spectrum of acute coronary syndrome , elderly patients had more complex comorbidities and worse outcome, yet they were less likely to undergo revascularization or to receive acute and long -term evidence - based medications. Age - related differences in rats with an myocardial infarction have not been well characterized in prior observational studies that often included only certain age groups or subjects with myocardial infarctionMETHODSSixty male Wistar rats with different aged (4 months and 18 months) were randomized into 4 months sham operated group ( group A, n = 6) , 4 months MI group ( group B, n = 6) , 4 months MI mobilized group ( group E, n = 6) , 4 months MI 6d group ( group G, n =6) and 4 months MI mobilized 6d group ( group H, n = 6) ; 18 months sham operated group ( group C, n = 6) ,18 months MI group ( group D, n =6) ,18 months MI mobilized group ( group F, n = 6) , 18 months MI 6d group ( group I, n = 6) and 18 months MI mobilized 6d group ( group J, n = 6) and MI was established by ligation of the anterior descending coronary artery in rats. Rats in group E, F, H and J were received subcutaneous injection of rhG - CSF 60 μg/kg-1· d-1 for 5 days. Echocardiography was performed before, 2 days , 7 days, 14 days and 28 days... |
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