Recombination Of Expression Of Human Trefoil Family Factor 2 (TFF2) In Lactococcus Lactis And Its Protective Effects On Gut Injury

The influences of damage of intestinal barrier on body are realized by two factors: (1) deterioration of normal histological structure and cell framework of the intestine, and (2) migration of microorganism and its metabolite from gut into environment. Thus, maintenance of normal gut structure and ecological balance among various bacteria in gut is a primary measure for protection of intestinal barrier.The normal flora in gut can stimulate immune reaction on a moderate level. This process helps to prevent excessive breed of potential pathogenic bacteria, and to decrease excessive inflammatory cytokine and to inhibit pathogenic activation of epithelial cell in gut. Thus, administration of probiotics promotes ecological balance in the intestine. Lactococcus lactis has been confirmed to be safe and effective, and used clinically for many years. Therefore, the author presumes that utilization of lactococcus lactis to express some active proteins or anti-inflammation cytokines in the gut will help protect the intestinal mucosa, leading not only to ecological balance in the intestine, but also to the intestine barrier, and becoming a novel approach for prevention of gut injury. The research of trefoil family factor (TFF) provides us a channel to validate this presumption.TFF is a kind of small molecular protein that is extensively expressed in epithelial cells of mammalian. TFF has 3 subtypes of homologous chromosome,...