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Research On Mechanism Of Acyl-CoA:Cholesterol Acyltransferase-2 In Diabetes Mellitus With Dyslipidaemia

Posted on:2007-12-25Degree:DoctorType:Dissertation
Country:ChinaCandidate:W Y ZhangFull Text:PDF
GTID:1104360185488136Subject:Endocrine and metabolic diseases
Abstract/Summary:PDF Full Text Request
More cardiovascular diseases occur in patients with type 2 diabetes. Yet, the link between diabetes and atherosclerosis is not completely understood. Among the metabolic abnormalities that commonly accompany diabetes are disturbances in the production and clearance of plasma lipoproteins. Moreover, development of dyslipidemia may be a harbinger of future diabetes. A characteristic pattern of diabetic dyslipidemia consists of low HDL, increased triglycerides, small dense LDL and postprandial lipemia, which is a major risk factor for subsequent cardiovascular diseases. Therefore, we will discuss the related mechanism that leads to diabetic dyslipidemia in this article.
Keywords/Search Tags:Dyslipidemia, Prevalence, Epidemiology, Diabetes, Dyslipidemia, Gene, Polymorphism, Cholesterol, acyl-CoA∶cholesterol acyltransferase-2, hepatic nuclear factor, estrogen, insulin, transcription regulation
PDF Full Text Request
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