Experimental Studies On The Killer Cells Co-Induced By The Soluble Head And Neck Tumor Antigens Plus AntiCD3mAb And Interleukin-2

A new kind of killer cells with immune competence, called TAK cell, was generated by the soluble head and neck tumor antigena plus anti-CD3mAb and interleukin-2. This paper systemically investigated its biological characteriatica. The results presented as follows:1. STA alone could not make the peripheral blood monocytes proliferate. However, STA combined with small amount of anti-CD3mAb and recombinant IL-2 could greatly lead to the gradient proliferation of PBMC.2. TAK cells had a more rapid expansion in vitro and less IL-2 dependence in comparison with LAK and CD3AK cells. The numbers of TAK cells increased 13-fold greater than those of LAK cells and 7-fold greater than those of CD3AK cells within four weeks' culture in vitro.3. One distinct difference was their ability to survive...