Irritable Bowel Sydrome Related Colonic Motility And The Potential Role Of Gut Hormone

The irritable bowel syndrome( IBS ) is one of the commonest disorder refered to gastroenterologists, but its pathogenesis is still a mystery. Epidermiologic survey and clinical observations suggested that physical and mental stress was assotiated with IBS. But the exact intensity and the underlying mechanism of the effects of stress on gut function remain unknown.In the present study, a series of clinical and experimental investigations were conducted to further identify the patterns of colonic motility in the IBS as well as to evaluate the effect of stress on colonic motility and the potential role of gut hormone was explored.Part I. A 2-hr manometry of decending-sigmoid colon was performed in patients with IBS. Neostigmine was administered following 1 hour of basal recording to determine the motor response. Plasma levels of some gut hormones were assessed simutaneously. At basal state,constipation-predominant IBS(Cp-IBS) showed less frequent contractions in sigmoid colon(SC) and a lower percentage of contractile time(PCT) both in the sigmoid and in the decending colon(DC), whereas in the diarrhea predominant(Dp-IBS) only the amplitude(AMP) of contractions in DC decreased. The motor index of SC was increased in Dp-IBS but decreased in Cp-IBS.Post-neostigmine motor response was some what different from healthy controls.In Cp-IBS, the elevation of AMP in SC was reduced in the initial 30 mins. In Dp-IBS, the motor response of SC as well as that of DC...