Studies On The Chemical Constituents In Two Species Plants Of Garcinia

Garcinia cowa Roxb. (Fam. Guttiferae) is mainly distributed in south of China and southeast of Asia. Its bark, young stem and leaf are used as an antipyretic medicine in folk. Garcinia xipshuanbannaesis (Fam. Guttiferae) is only distributed in Xishuanbanna of China. In order to obtain a more comprehensive understanding of their effective physiological constituents, in this doctoral dissertation, the systematic phytochemical studies have been carried out and cytotoxicity of twelve compounds on different cancerous cell lines are evaluated.Twenty-six and seven compounds were isolated from the ethanol extracts of the young stems and the fruits of G. cowa by various column chromatographies respectively. On the basis of spectral ananysis (IR, UV, EI-MS, ESI-MS, FAB-MS, LC-MS/MS³, ¹H NMR, ¹³C NMR, DEPT, ¹H-¹H COSY, HSQC, HMBC), these compounds were elucidated, of which seven were new. A new compound and thirteen compounds were isolated and elucidated from the ethanol extracts of the fruits of Garcinia xipshuanbannaesis by the upper ways. Eight new compounds were as follows: 1, 5, 6-Trihydroxy-3-methoxy-4-(3-hydroxyl-3-methylbutyl)xanthone (CS1), 1, 5-Dihydroxy-3-methoxy-6', 6'-dimethyl-2H-pyrano (2', 3': 6, 7)-4-(3-methylbut-2-enyl)xanthone (CS2), Garccowaside A (CS3), Garccowaside B (CS4), Garccowaside C (CS5), Garccowa aldehyde (CS26), Guttiferone K (CF2), Garcxipshuanbannaol (X14). The known compounds were identified as 1, 3, 5-trihydroxy-6', 6'-dimethyl-2H-pyrano (2', 3': 6, 7) xanthone (CS6), dulxanthone A...