Effects Of ETOMIDATE ON Synaptic Transmission And Plasticity In HIPPOCAMPAL CA1 REGION OF RATs

The precise action of the general anaesthetics is still not well understood since that was clinical used firstly 160 years ago. There has been an explosion of studies over the past decade on the effects of general anesthetics on putative targets in the central nervoussystem, and show that they are much more selective than is usually appreciated and may act by binding to only a small number of targets. At clinical concentrations these targets are most likely to be postsynaptic ligand-gated ion channels, among of which exhibit a large variance of the sensitivities and specificities. Further characterization of the sites of the interaction with anesthetics, as the most important aspect, the possible relationship between these channels and the producton of general anesthesia are the main point and difficulty.Etomidate is an intravenous general anaesthetics in clinical that has Ideal pharmacologic characteristic and distinct chemical constitution. In vitro studies showed that a large number of postsynaptic ligand-gated ion channels are sensitive to etomidate under it's clinical concentrations, including GABAA receptor and NMDA receptor, and GABAA receptor is the most sensitive one; therefore, most studies of the...