Abstract: ET-11-31, a novel member of the endothelin family comprising 31 amino acids and derived from the selective hydrolysis of big ET-1 by chymase. Although the peripheral effects of ET--11-31 have been well determined, the cardiovascular role of ET--11-31 is not fully understood. Our study suggested that administration of ET--11-31 through coronary artery increased blood pressure of rats. Central administration of ET--11-31 produced biphasic cardiovascular effects. The central effects of ET--11-31 which were mediated through ETA receptors and did nothing with ETB receptors, result from ET--11-31 converting to ET--11-21 ET--11-31 increase [Ca2+]I, but 10-8 mol/L terminated [Ca2+]I, which were partly attenuated by phosphoramidon.
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