Classification Of 534 Cases Of Neuroepithelial Tumor And Study Of 1pLOH In Chinese Patients With Oligodendroglioma

The clinical-pathological characteristics, genetic change and the biological behaviors of neuroepithelial tumors were reflected in the new WHO classification of brain rumor. The new classification included new concepts into many types of the tumors. The aim of this paper is to understand the new classification and put it into practice, and to show the change of constituent ratio of the neuroepithelial tumor after diagnosis using the new WHO classification, and also to carry out the lpLOH testing in oligodendroglial tumors, thereby to provide basic data for further basic and clinical study about the neuroepithelial tumor. Methods: 534 cases of the neuroepithelial tumor treated in PLA general hospital during 4 years(between January, 2000 to July,2004) were re-diagnosed using the new WHO classification based on the immunocytochemistry findings(ABC method) with more than 10 types of antibody, and the incidence was analyzed. Then, 14 cases out of 534 gliomas which undergone operation in late 1 year( 7 cases of oligodendroglial tumor and 7 cases of non-oligodendroglial glioma) were selected and tested the 1p LOH status using FISH technique. The relation between 1p LOH and patient age, tumor site, pathological characteristics and grade was evaluated. Results: Among the 534 cases, 317 cases (39.34% ) were astrocytic tumors; 51 cases (9.55% ) were oligodendroglial tumors; 67 cases ( 12.55% ) were ependymal tumors; 41 cases (7.68% ) were embryonal tumors of the neuroepithelial tissue; 24 cases (4.49% ) were neuronal and mixed neuronal-glial tumors, including 5 cases ganglioglioma, 2 cases gangliocytoma, 1 case dysplastic gangliocytoma of cerebellum,2 cases paraganglioma of the filum terminale, 8 cases central neurocytoma, and 6 cases dysembryoplastic neuroepithelial tumour; 12 cases (2.25% ) were choroid plexus tumor; 16 cases(3.00%) were mixed glioma; 1 case(0.19%) was glial tumour of uncertain origin(gliomatosis cerebri) and 3 cases were pineal parenchymal tumour; 2 cases(0.37%) were olfactory neuroblastoma. The result of...