Relationship Between Gastrointestinal Motility Dysfunction Induced By Multiple Organ Dysfunction Syndrome And Interstitial Cells Of Cajal And Therapeutic Mechanism Of Dachengqi Granula

Objective: To investigate the mechanism of gastrointestinal motility dysfunction induced by multiple organ dysfunction syndrome (MODS) and the mechanism of Dachengqi granula for treatment of MODS. Materials and Methods: One hundred and eleven Wistar rats were randomly divided into three groups, which were the normal group, the MODS group, and the group treated with Dachengqi granula. The following methods were used to detect the gastrointestinal function: (1)to detecte the gastrointestinal transit index by carbo medicinalis progradation experiment; (2)to measure the circumference of small intestine; (3)to record the frequency and amplitude of slow wave in myoelectricity of gastric corpus, gastric antrumin and intestine in vivo; (4)to record the frequency and amplitude of spontaneous contraction of gastric corpus, gastric antrum and intestinal muscle strip in vitro. Result: Compared the result of the MODS group with the normal group: the gastrointestinal transit index was obviously reduced, and the circumference of small intestine was significantly enlarged. The frequency and amplitude of slow wave in myoelectricity of gastric corpus, gastric antrum and intestine of the MODS group were slower and lower than the normal group. The frequency and amplitude of spontaneous contraction of gastric corpus, gastric antrum and intestinal muscle strip were decreased anddescend. Compared the result of the therapeutic group with the MODS group: the mortality was decreased, the gastrointestinal transit index was obviously increased, and the circumference of small intestine was reduced. The frequency and amplitude of slow wave in gastric corpus, gastric antrum and intestine of the therapeutic group were faster and higher than the MODS group. The frequency and amplitude of spontaneous contraction of gastric corpus, gastric antrum and intestinal muscle strip were raised and enhanced. Conclusion: Gastrointestinal motility dysfunction can be caused by MODS. Dachengqi granula can improve the gastrointestinal motility dysfunction, accelerate the gastrointestinal transmission velocity, increase vermiculation and reduce mortality rate. There were obvious effect on the prophylaxis and the treatment of MODS.