| Objective To observe the comfrey oil Cupping treating plaque psoriasis’clinical efficacy and safety. Based on the presence of symmetry meridian theory, verify the meridian effect of psoriasis.Method Test 1,88 cases of plaque psoriasis were randomly divided into Comfrey Oil Cupping group 30 cases, the Comfrey Oil topical group 30 cases, and the waiting group 28 cases. The first group received Comfrey Oil Cupping. The second group received Comfrey Oil topical treatment, the waiting group without both applying Cupping and topical therapy.3 groups were conventional oral Chinese medicine treatment. Treatment time was 4 weeks.3 groups were observed PASI score, clinical efficacy, the extent of scaly lesions, infiltration, erythema situation, pruritus, quality of life scores and adverse reactions. Test 2,60 patients with plaque psoriasis patients having symmetrical parts lesions were randomly divided into two groups. Observed group of 30 patients, the waiting group of 30 cases. Select the side of the observation group symmetrical lesions receiving Comfrey Oil Cupping treatment. The control side was without both applying Cupping and topical therapy. The waiting group was without both applying Cupping and topical therapy. Both groups were receiving conventional oral Chinese medicine treatment. Treatment time was 8 weeks. Observation both group’PASI score, clinical efficacy, the extent of scaly lesions, infiltration, erythema situation, pruritus, and adverse reactions.Results Test 1, the lesion area and severity index (PASI) scores, all the three groups after treatment, were significantly lower than before treatment (P<0.01). In the three groups after treatment PASI score was no significant difference (P> 0.05), but compared the Comfrey Oil Cupping group and the waiting group, the former was lower than the latter (P<0.05). The PASI score difference of 3 groups’before and after treatment, the difference among groups was statistically significant (P<0.01). Pairwise comparison Comfrey Oil Cupping group was lower than the Comfrey Oil topical group and the waiting group (P<0.01).In Comfrey Oil Cupping group 30 patients, none cases recovered patients were cured, markedly effective 12 cases (40.00%), effective 14 cases (46.67%), invalid 4 cases (13.33%), the total effective rate was 86.67%. In the Comfrey Oil topical group 30 patients, none cases were cured and markedly effective, effective 13 cases (43.33%), invalid 17 cases (56.67%), the total effective rate was 43.33%. In the waiting group 28 patients, none cases were cured and markedly effective, effective 10 cases (35.71%), invalid 18 cases (64.29%).The total effective rate was 35.71%. The difference among the three groups was statistically significant (P<0.01). Pairwise comparison, the Comfrey Oil Cupping group was better than the Comfrey Oil topical group (P<0.01) and the waiting group (P<0.01), the difference between the Comfrey Oil topical group and the waiting group was not statistically significant (P> 0.05).For itching, the three groups were significantly improved after treatment than before (P<0.01). the difference among the three groups were statistically significant (P<0.01).The lesion area, the Comfrey Oil Cupping group after treatment was lower than before treatment (P<0.01).After treatment,the Comfrey Oil topical group and the waiting group was not statistically significant compared with before treatment (P> 0.05). The differences among the Comfrey Oil Cupping group, the Comfrey Oil topical group and the waiting group were statistically significant (P<0.01).Aspects of infiltration, after treatment, the three groups were significantly reduced compared with before treatment (P<0.01). There were statistical significance among the three groups(P<0.01).The scaly extent, after treatment, the Comfrey Oil Cupping group and the Comfrey Oil topical group were lower than before treatment (P<0.01), compared the result after and before treatment in the waiting group, it showed no significant difference (P> 0.05).After treatment, compared among the three groups, the differences were statistically significant (P<0.01).For redness, the three groups after treatment were significantly improved compared with before treatment (P<0.01). the differences among the three groups were statistically significant (P<0.01).For the quality of life score, the three groups were significantly lower after treatment than before (P<0.01). the differences among the three groups were not statistically significant (P>0.05).Test 2, the observation group compared with the waiting group, PASI score after 8 weeks of treatment,the observation group and the waiting group were significantly lower than before (P<0.01).compared after 8 weeks with 4 weeks, the two groups’scores were significantly lower than before treatment (P<0.01). After 8 weeks the difference between the two groups was statistically significant (P<0.01).Itching, compared with before treatment, the observation group was significantly reduced after 8weeks (P<0.01), compared to 4 weeks, the difference was statistically significant (P<0.01). In the the waiting group,it was significantly improved compared with before treatment (P<0.01), compared to 4 weeks there was no significant difference (P> 0.05). After 8 weeks compared between the two groups was statistically significant (P<0.01).Lesion area, compared the results after and before treatment in the observation group,it was significantly reduced after 8weeks of treatment (P<0.01), and compared with 4 weeks, the difference was statistically (P<0.01). it was no significant change in the waiting group after treatment (P> 0.05), no significant difference between the two groups after 8 weeks (P> 0.05).For the infiltration after 8 weeks in the observation group,it was significantly reduced (P<0.01). Compared with 4 weeks, the difference was statistically significant (P<0.01). In the waiting group, it was significantly reduced after 8weeks (P<0.01), compared with 4 weeks,it was no significant difference (P> 0.05).Aafter 8 weeks,compared between the two groups was statistically significant (P<0.01).For the scales, both of the two groups were significantly reduced after 8 weeks (P<0.01), compared to 4 weeks, the difference was statistically significant (P<0.01), After 8 weeks,compared between the two groups,there was statistically significant (P<0.01).The erythema, it was significantly reduced after 8 weeks in the observation group than before (P<0.01), compared to 4 weeks, the difference was statistically significant (P<0.01). In the waiting group,there was not statistically significant (P> 0.05), compared with 4 weeks,there was no significant difference (P> 0.05). After 8 weeks compared between the two groups was statistically significant (P<0.01).Rrelatively efficient, observation group 4 cases were cured (6.67%), markedly effective 27 cases (45.00%), effective in 21 cases (35.00%), invalid 8 cases (13.33%), the total effective rate 86.67%. Waiting group was no cure patients, markedly effective 4 cases (6.67%) effective 12 cases (20.00%), ineffective 44 cases (73.33%), the total effective rate 26.67%. The observation group was better than the waiting group.Comparison of patients treated with treat and control sides, PASI score after 8 weeks of treatment before treat and control sides were significantly lower than before treatment (P<0.01). Compared to 4 weeks of treatment, the two groups were both significantly lower, (P<0.01). The difference between the two sides after 8 weeks was statistically significant (P<0.01).Itching, two groups 8 weeks after treatment compared with before treatment were significantly lower (P<0.01). Compared between 8 weeks and 4 weeks of treatment, two scores were not statistically significant (P> 0.05). The difference between the two sides after 8 weeks was statistically significant (P<0.01).Scales, the treat side after 8 weeks of treatment was significantly reduced than before (P<0.01), and compared with 4 weeks,the difference was significantly (P<0.01). The control side after 8 weeks was significantly improved compared with before (P<0.01). Compared to 4 weeks,there was no significant difference (P> 0.05). After 8 weeks, compared between the two sides, there was statistically significant (P<0.01).Erythema, the two groups after 8 weeks treatment compared with before,there was significantly reducement (P<0.01). Compared to 4 weeks, the difference was statistically significant (P<0.01). After 8 weeks compared between the two sides, there was no significant difference (P> 0.05).Infiltration, the treat side after 8 weeks of treatment compared with before, there was significantly reducement (P<0.01). Compared with 4 weeks, the difference was statistically significant (P<0.01). The control side after 8 weeks was significantly improved compared with before (P<0.01), compared to 4 weeks,there was no significant difference (P> 0.05). After 8 weeks compared between the two sides was statistically significant (P<0.01).Lesion area, the treat side after 8 weeks of treatment compared with before,it reduced significantly (P<0.01). Compared with 4 weeks, the difference was statistically significant (P<0.01). the control side after 8 weeks compared with before treatment, it was significantly improved (P<0.05), compared to 4 weeks,there was no significant difference (P>0.05), no significant difference between the two sides after 8 weeks (P> 0.05).The control side of observation group compared with the waiting group, PASI score after 8 weeks of treatment controls side and waiting group were significantly lower than before (P<0.01).8 weeks compared to 4 weeks of treatment, the two groups were significantly lower (P<0.01). The difference between the two groups after 8 weeks was statistically significant (P<0.01).Itching, after 8 weeks of treatment in both groups compared with before treatment, they were decreased significantly (P<0.01), no statistically significant after 4 weeks of treatment compared with 8 weeks (P> 0.05). After 8 weeks compared between the two groups was statistically significant (P<0.01).The lesion area, after 8 weeks compared with the control side before treatment, it decreased significantly (P<0.05). In the waiting group,the difference between after 8 weeks and before treatment was not statistically significant (P> 0.05). Two groups of 8 weeks after treatment comparing 4 weeks was not statistically significant (P> 0.05), no significant difference between the two groups after 8 weeks treatment(P> 0.05).Infiltration, the two groups after 8 weeks of treatment compared with before treatment were decreased significantly (P<0.01), no statistically significant after 4 weeks of treatment, compared with 8 weeks (P> 0.05). Between the two groups after 8 weeks, the difference was statistically significant (P<0.01).Scales, the two groups after 8 weeks of treatment were significantly lower than before treatment (P<0.01). Compared to 8 weeks and 4 weeks of treatment, both groups were significantly lower (P<0.05, P<0.01). The difference between the two groups after 8 weeks was statistically significant (P<0.01).Erythema, the control side after 8 weeks of treatment compared with before treatment was significantly reduced (P<0.01), compared to 4 weeks, the difference was statistically significant (P<0.01).The waiting group 8 weeks later compared with before treatment was no significant improvement (P> 0.05), compared to 4 weeks, there was no significant difference (P> 0.05). After 8 weeks compared between the two groups, the difference was statistically significant (P<0.01).Conclusion Comfrey Oil Cupping treating plaque psoriasis have a good effect and no adverse reactions. Comfrey Oil Cupping for plaque psoriasis 8 weeks treatment efficacy increase over 4 weeks. By comparing themselves to go further confirmed the effect of Comfrey Oil Cupping treating for plaque psoriasis. Control side is more effective than the waiting group, to prove the existence of meridians effect on the efficacy. Symmetry intractable skin lesions showed consistency with the phenomenon of symmetry meridian, it might have the effect of the meridian. Under the guidance of Meridian, we can increase the distal end of the treatment on the basis of local treatment, and expand the range of available treatments, increasing the clinical efficacy. |
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