Study On The Synthesis And Application Of Dendrimers

This dissertation consists of five chapters, including the overview of the dendrimers, synthesis and application of novel PAMAM-FCD dendrimers; synthesis and application of novel PAMAM-AND dendrimers; synthesis and application of novel PAMAM-BPA dendrimers; the conclusion and prospect of the present research work.In chapter one, highlights of new finding in dendrimers and its significance in modern biological medicine and catalyst, nanometer materials, light, electricity and so on. The history and background of dendrimers are viewed. The brief introduction and current development of the dendrimers in biological medicine, catalyst, nanometer, light and electricity materials, film materials, liquid crystal, dope, surfactant and so on are given. The research proposal for this dissertation is also presented.In chapter two, the research work on the synthesis and application of the novel PAMAM-FCD dendrimers is described. The results enlarge the application range of dendrimers and have positive significance for developing the application of organic/inorganic hybrid materials, host and guest. This chapter is divided into two sections.In section one, a series of PAMAM-FCD dendrimers from generation one to generation five are prepared. PAMAM dendrimer is a kind of dendrimer having many groups at their periphery. The PAMAM are modified with the 2-Fluorenecarboxaldehyde, and a series of dendrimers of PAMAM-FCD areprepared, with the Schiff-base as their periphery groups. The unmodified PAMAM dendrimer is viscous; however, the modified products are solid powder, so their structure is easily characterized by IR, ^NMR, MALDI-TOF, and UV. The PAMAM is hardly dissolving in CHClaand CHC1, however the modified product can dissolve in these solvents, so the properties of these PAMAM-FCD dendrimers in these solvents are studied. The solution of the different generation of PAMAM-FCD can emit blue fluorescent, when excited with UV light. The different metal ions are titrated to the solution of the different generation of PAMAM-FCD dendrimers, and their fluorescent properties are studied. When the metal ions, such as irons, copper, cobalt, nickel ions are dropped into the solution of the different generation of PAMAM-FCD, the fluorescent intensity of the PAMAM-FCD solution is increased obviously, generally, irons, copper, cobalt ions are all fluorescent quenching agent. The fluorescent results for the titration of Snshow that the Sn can chelate with N atom according to 1:1, and the fluorescent intensity changes according to some rule, which show that the chelating course is from the periphery of the PAMAM-FCD dendrimer to interior, so the metal/organic dendrimer hybrid materials with fine controlled structure and different ratio of metal to N atom are promising to be received. These hybrid materials are promising to be the hybrid materials which can emit blue fluorescent. The fluorescent results of the titration of iron, copper, and other metal ions to these dendrimers do not show obvious chelating order.In section two, the host properties of the PAMAM-FCD for the small, molecules guest are studied, and the host properties of these dendrimers for the Eosin B and phloxine are studied, the result show that the absorbing properties of the PAMAM-FCD dendrimers for these small molecules are related to the generation and the concentration of the dendrimers, the concentration and pH ofthe small molecules. With the generation of PAMAM-FCD increasing, the concentration of the hosted small molecules is also increasing. For the same generation of PAMAM-FCD, the concentration of the hosted small molecules is increasing with the concentration of the dendrimers and the concentration of the dyes. No matter the Eosin B and phloxine, the hosting properties of these dendrimers are all related to the pH of these dyes. In the acid condition, the small molecules are easily hosted in the dendrimer. As the human's stomach juice is acid, so using the properties of the dyes easily encapsulated in the dendrimer in the acid condition, these dendrime...